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Mendelian randomization analysis reveals causal effects of migraine and its subtypes on early-onset ischemic stroke risk.

Scientific reports - 28 Dec 2024

Zhang Rui, Niu Peng-Peng, Li Shuo, Li Yu-Sheng

Abstract excerpt

Previous observational studies have suggested at a potential link between migraine, particularly migraine with aura, and the susceptibility to early-onset ischemic stroke. We aimed to investigate the causal effects of genetically determined migraine and its subtypes on the risk of early-onset ischemic stroke using the two-sample Mendelian randomization method. Genetic instrumental variables associated with...

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Age of Onset
Ischemic Stroke
Linkage Disequilibrium
Mendelian Randomization Analysis
Migraine Disorders

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Migraine with Aura

Migraine without Aura

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PMID: 39733194
DOI: 10.1038/s41598-024-83344-0
PMCID: PMC11682154

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