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Relationship Between Migraine and Alzheimer's Disease: A Study of Mendelian Randomization.

Brain and behavior - 1 Jan 2026

Bi Ran, Zhao Weimin, Li Jiaoxuan, Han Songji, Qi Haotian, Liu Jian, Wu Jinpu, Xu Shengxian, Sun Zhongda, Liu Zhenru

Abstract excerpt

BACKGROUND: Given inconsistent evidence regarding the migraine-Alzheimer's disease association, this Mendelian randomization (MR) study examines their potential causal relationship. METHODS: GWAS summary statistics for migraine and Alzheimer's disease were acquired from the IEU Open GWAS repository. We implemented a multi-stage MR framework comprising (1) univariate analysis, (2) independent replication, (3)...

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Alzheimer Disease
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Migraine Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 41581199
DOI: 10.1002/brb3.71081
PMCID: PMC12832092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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