Preliminary ultrastructural analysis suggests phenotype-specific myofiber alterations in idiopathic inflammatory myopathies.

doi:10.1038/s41598-026-42717-3

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Article

Preliminary ultrastructural analysis suggests phenotype-specific myofiber alterations in idiopathic inflammatory myopathies.

Scientific reports - 6 Mar 2026

Aguilar-Vazquez Andrea, Juarez-Gomez Christian, Gonzalez-Gauna Emiliano, Medrano-Ramirez Gabriel, Vargas-Cañas Steven, Vargas-Guerrero Angelica, Gutiérrez-Hernández José Manuel, Toriz Guillermo, Gomez-Rios Cynthia-Alejandra, Medina-Preciado Jose-David, Chavarria-Avila Efrain, Martin-Marquez Beatriz-Teresita, Pizano-Martinez Oscar, Martinez-Garcia Erika-Aurora, Perez-Vazquez Felipe, Sandoval-Garcia Flavio, Salazar-Paramo Mario, Rubio-Arellano Edy-David, Becerra-Jimenez Jose, Garcia-Ordoñez Gabriela, Gaspar-Ruiz Arahi, Ramos-Hernandez Alejandra, Cabrera-Lopez Maribell, Llamas-Garcia Arcelia, Vazquez-Del Mercado Monica

Abstract excerpt

Idiopathic inflammatory myopathies (IIM) comprise a heterogeneous group of autoimmune muscle diseases with variable patterns of muscle damage. In this multicentric cross-sectional study, we employed scanning electron microscopy (SEM) to characterize ultrastructural alterations in muscle biopsies from quadriceps (n = 29) and deltoid (n = 41) of 70 IIM patients classified by ENMC (European Neuromuscular Centre)...

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PMID: 41792374
DOI: 10.1038/s41598-026-42717-3
PMCID: PMC13079867

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