Article
A high-throughput screening procedure for enhancing pyruvate production in Candida glabrata by random mutagenesis.
Bioprocess and biosystems engineering - 1 May 2017
Luo Zhengshan, Zeng Weizhu, Du Guocheng, Liu Song, Fang Fang, Zhou Jingwen, Chen Jian
Abstract excerpt
Candida glabrata is one of the most promising pyruvate producers. A series of experiments was conducted to enhance pyruvate production by C. glabrata via metabolic and genetic engineering. Here, a novel screening strategy, which combined atmospheric and room temperature plasma-based random mutagenesis and high-throughput screening (HTS), was used to screen for high pyruvate-producing mutants that could use cheap...
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