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Primary Angiosarcomas of the Thyroid: New Insights Into the Genetic Background and Potentially Targetable Therapeutic Markers of an Ultrarare Disease.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2026

Ingenwerth Marc, Pretzell Ina, Bednaric Elisabeth, Basol Cagla, Herold Thomas, Kalbourtzis Stavros, Brandenburg Tim, Machlah Yara, Führer-Sakel Dagmar, Hamacher Rainer, Theurer Sarah

Abstract excerpt

Thyroid angiosarcomas (TASs) are listed as a distinct entity in the World Health Organization classification of malignant tumors and represent highly aggressive neoplasms, with early metastasis and overall survival of few months. Owing to their rarity, data on tumorigenesis, molecular alterations, and potential therapeutic targets remain limited. We present a series of 16 primary TAS subjected to systematic...

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Identifiers

PMID: 41786211
DOI: 10.1016/j.modpat.2026.100987

Genes

FAP
MYC
FOLR1
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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