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Impacts of host genetics on gut microbiome composition in Alzheimer's disease.

Microbiome - 5 Mar 2026

Liu Jinxin, Cao Jixin, Jia Longhao, Gan Ziquan, Zhao Xingzhong, Yang Anyi, Lai Senying, Chen Feng, Yang Yucheng T, Zhao Xing-Ming

Abstract excerpt

BACKGROUND: Host-microbiome interactions play essential roles in the development of Alzheimer's disease (AD), yet the host genetic impacts on gut microbial alterations in AD remain poorly understood. RESULTS: Here, we simultaneously profiled host genotype and gut microbiome in 252 Chinese individuals with varying degrees of cognitive disability. Using the latent Dirichlet allocation topic model, we identified the...

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Identifiers

PMID: 41782023
DOI: 10.1186/s40168-026-02342-8
PMCID: PMC13069797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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