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Article

Metformin improves RAN protein pathology, alternative splicing, and behavioral phenotypes in SCA8 mice.

Life science alliance - 1 May 2026

Romano Lisa El, Tsukagoshi Setsuki, Davey-Osuch Emily E, Ajredini Ramadan, Manasi Kamat, Ortiz Tala Vr, Rijos Eduardo, Bourgon Nathan J, Ames S Elaine, Garrett Timothy J, Cleary John D, Wang Eric T, Ranum Laura Pw

Abstract excerpt

Spinocerebellar ataxia type 8 (SCA8) is a member of a group of dominantly inherited, debilitating neurological diseases caused by CAG•CTG expansions for which there are no effective treatments. RAN translation, which was discovered in SCA8, has previously been shown to occur across CAG and CUG expansion transcripts, making treatments for SCA8 potentially relevant to a broad group of diseases, including SCA1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41771688
DOI: 10.26508/lsa.202503555
PMCID: PMC12954051

Genes

RAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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