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In Search of the Most Significant Potential G-Quadruplexes in SARS-CoV-2 RNA: Genomic Analysis.

Viruses - 16 Feb 2026

Zarudnaya Margarita, Voiteshenko Ivan, Hurmah Vasyl, Shyryna Tetiana, Nyporko Alex, Platonov Maksym, Roszak Szczepan, Rasulev Bakhtiyor, Kapusta Karina, Gorb Leonid

Abstract excerpt

G-quadruplexes (G4s) are emerging as potential antiviral targets. SARS-CoV-2 genomic RNA contains 42 G-rich regions harboring putative G-quadruplex-forming sequences (PQSs). Here, we performed a systematic genomic and structural analysis of SARS-CoV-2 PQSs. It was proposed that non-G-tetrads or different triads may stabilize most G4s in this RNA. Many G4s may include the most stable U·A-U triad. Several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41754596
DOI: 10.3390/v18020253
PMCID: PMC12945054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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