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Targeting RNA G-quadruplex with repurposed drugs blocks SARS-CoV-2 entry

26 Jan 2023

Abstract excerpt

The rapid emergence of SARS-CoV-2 variants of concern, the complexity of infection, and the functional redundancy of host factors, underscore an urgent need for broad-spectrum antivirals against the continuous COVID-19 pandemic, with drug repurposing as a viable therapeutic strategy. Here we report the potential of RNA G-quadruplex (RG4)-targeting therapeutic strategy for SARS-CoV-2 entry. Combining...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 36701392
DOI: 10.1371/journal.ppat.1011131

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