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Article

Bile Salt Tolerance Determines Intestinal Colonization Efficacy of Heyndrickxia coagulans: A Phenotypic and Genomic Study.

International journal of molecular sciences - 20 Feb 2026

Jin Yi-Wei, Chen Feng, Cao Jiang

Abstract excerpt

The probiotic efficacy of H. coagulans relies on the bile salt tolerance of its vegetative cells, yet direct evidence linking this trait to intestinal colonization remains limited. This study integrated phenotypic screening, in vitro gastrointestinal simulation, in vivo colonization assays, and comparative genomics to address this gap. Among 50 strains, two highly bile salt-tolerant isolates (ATCC 7050 and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41752157
DOI: 10.3390/ijms27042022
PMCID: PMC12940431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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