Multi-Scale Mapping of Gene Expression from Whole-slide Images for Identifying Phenotype-Associated Subpopulations.

Abstract excerpt

Discovery of phenotype-associated subpopulations is critical for targeted therapies and prognostic biomarker discovery, which requires multi-scale gene expression. Deep learning advancements have enabled cost-effective genetic alteration inference from whole-slide images (WSIs), but most methods operate at a single scale. This study presents BiSCALE, a deep-learning framework that predicts gene expression from...

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