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Article

Molecular characterisation of the trafficking rescue of defective ABCB4 variants by roscovitine analogues.

Scientific reports - 25 Feb 2026

Banet Manon, Crespi Veronica, Elie Jonathan, Riahi Yosra, Lakli Mounia, Mareux Elodie, Gonzales Emmanuel, Jacquemin Emmanuel, Meijer Laurent, Lapalus Martine, Di Meo Florent, Falguières Thomas

Abstract excerpt

ABCB4 is expressed at the canalicular membrane of hepatocytes and is responsible for the secretion of phosphatidylcholine into bile. Genetic variations of ABCB4 are associated with rare cholestatic liver diseases, the most severe being progressive familial intrahepatic cholestasis type 3, for which most of patients require liver transplantation before adulthood. Therefore, the development of alternative...

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Topics

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Cholestasis, Intrahepatic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Molecular Docking Simulation

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Source

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Identifiers

PMID: 41735377
DOI: 10.1038/s41598-026-39840-6
PMCID: PMC13043924

Genes

ABCB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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