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Article

Risk Assessment for Drug-Induced Hyperbilirubinemia: A Mechanistic Approach.

CPT: pharmacometrics & systems pharmacology - 1 Mar 2026

Kumar Rajeev, Kumar Ansu, Alam Aftab, Mundkur Yatin, Wingrove James

Abstract excerpt

Hyperbilirubinemia, characterized by elevated total blood bilirubin levels including both unconjugated and conjugated forms, serves as a diagnostic marker for drug-induced liver toxicity associated with a wide range of medications. This study aimed to develop a mechanistic model for assessing hyperbilirubinemia risk using genetic markers. We developed an ordinary differential equation (ODE)-based mechanistic...

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Share to Bilirubin
Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucuronosyltransferase

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Share to Liver-Specific Organic Anion Transporter 1

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Share to Multidrug Resistance-Associated Protein 2

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Source

Open in PubMed Open full text

Identifiers

PMID: 41734150
DOI: 10.1002/psp4.70037
PMCID: PMC12931630

Genes

UGT1A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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