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The relationship between MMP-2 and TIMP-2 gene polymorphisms and skin barrier function, inflammatory cytokine levels in acne patients.

Expert review of clinical immunology - 1 Feb 2026

Huang Suling, Fang Lijia, Zhang Meina, Sun Shuxian, Zhi Huixian, Zhu Yuguang, Zhang Hong

Abstract excerpt

OBJECTIVE: This study aimed to investigate the association between MMP-2 rs243865 and TIMP-2 rs8179090 gene polymorphisms and skin barrier function, as well as inflammatory cytokine levels, in acne patients, to explore potential genetic mechanisms underlying acne pathogenesis. METHODS: A total of 200 acne patients and 100 healthy controls were enrolled. Genotyping was performed using PCR-RFLP. Skin barrier...

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PMID: 41730533
DOI: 10.1080/1744666X.2026.2636646

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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