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Hypertrophic post-acne scarring is associated with a single nucleotide polymorphism (rs243865) in the matrix metalloproteinase-2 gene.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG - 1 Dec 2020

Gupta Navya, Bishnoi Anuradha, Mathew Don, Arora Amanjot, Handa Sanjeev, Kaur Jyotdeep, De Dipankar, Pal Arnab

Abstract excerpt

BACKGROUND AND OBJECTIVE: Aberrant tissue expression of matrix metalloproteinases has been observed in acne. Our objective was to study the relevance of MMP-2 (-1306 C/T, rs243865) and TIMP-2 (-418 G/C, rs8179090) single nucleotide polymorphisms (SNP) in acne and post-acne scarring. PATIENTS AND METHODS: 512 patients (169 having acne without scarring, 319 having atrophic acne scarring, 24 having hypertrophic acne...

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PMID: 33373134
DOI: 10.1111/ddg.14338

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