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Article

Functional assessment of a convergent gene network underlying allergic diseases and IgE.

The Journal of allergy and clinical immunology - 1 Jul 2026

Eranti Pradeep, Vernet Raphaël, Linhard Christophe, Ge Bing, Beaumier Laura, Madore Anne-Marie, Chanoine Sébastien, Tremblay Bénédicte L, Shao Xiaojian, Pin Isabelle, Lathrop Mark, Grundberg Elin, Siroux Valérie, Pastinen Tomi, Laprise Catherine, Bouzigon Emmanuelle, Demenais Florence

Abstract excerpt

BACKGROUND: The relationships between allergic diseases (AD) and IgE levels are complex. OBJECTIVE: We sought to identify genes associated with AD and IgE having close proximity in the interactome and to elucidate the associated biological mechanisms. METHODS: We integrated a comprehensive interactome with data from genome-wide (GWAS) and epigenome-wide (EWAS) association studies of AD and IgE levels,...

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PMID: 41724407
DOI: 10.1016/j.jaci.2026.02.009

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