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Protective Effect of Mitochondrial ND2 C5178A Gene Mutation on Cell and Mitochondrial Functions.

Oxidative medicine and cellular longevity - 1 Jan 2021

Tian Liuyang, Zhu Chao, Yang Huanwan, Li Yang, Liu Yuqi

Abstract excerpt

BACKGROUND: Mitochondrial NADH dehydrogenase subunit 2 (MT-ND2) m. 5178C>A gene mutation has protective effects against various diseases, but the molecular mechanism is still unclear. In previous study, we found a heteroplasmy level of MT-ND2 m. 5178C>A mutation in normotensive controls. Peripheral blood samples were obtained from essential hypertension individuals carrying the mutation and healthy controls...

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Identifiers

PMID: 34336093
DOI: 10.1155/2021/4728714
PMCID: PMC8315857

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