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Article

Integrated analysis of the molecular pathogenesis of FDXR-associated disease.

Cell death & disease - 4 Jun 2020

Slone Jesse D, Yang Li, Peng Yanyan, Queme Luis F, Harris Belinda, Rizzo Stacey J Sukoff, Green Torrian, Ryan Jennifer L, Jankowski Michael P, Reinholdt Laura G, Huang Taosheng

Abstract excerpt

The mitochondrial flavoprotein ferredoxin reductase (FDXR) is required for biogenesis of iron-sulfur clusters and for steroidogenesis. Iron-sulfur (Fe-S) clusters are ubiquitous cofactors essential to various cellular processes, and an increasing number of disorders are associated with disruptions in the synthesis of Fe-S clusters. Our previous studies have demonstrated that hypomorphic mutations in FDXR cause a...

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Identifiers

PMID: 32499495
DOI: 10.1038/s41419-020-2637-3
PMCID: PMC7272433

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