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Causal effects of immune cell populations on biological aging: a Mendelian randomization study.

Biogerontology - 15 Nov 2025

Fu Jingfeng, Wu Wei, Shen Shangren

Abstract excerpt

While immune system involvement in aging is increasingly recognized, causal relationships between specific immune cell populations and biological aging indicators remain unclear. We aimed to identify immune targets influencing aging trajectories to inform future immunomodulatory interventions. We conducted two-sample Mendelian randomization (MR) analysis using immunophenotype GWAS data (3,757 Sardinian...

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Aged
Aging
CD14 gene
Genome-Wide Association Study
Mendelian Randomization Analysis
Phenotype

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PMID: 41240153
DOI: 10.1007/s10522-025-10354-4

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CD14
CD28

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