Article
How do members of the public expect to use variants of uncertain significance in their health care? A population-based survey.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 May 2023
Mighton Chloe, Clausen Marc, Shickh Salma, Baxter Nancy N, Scheer Adena, Sebastian Agnes, Muir Sarah M, Kim Theresa H M, Glogowski Emily, Schrader Kasmintan A, Regier Dean A, Kim Raymond H, Lerner-Ellis Jordan, Bayoumi Ahmed M, Thorpe Kevin E, Bombard Yvonne
Abstract excerpt
PURPOSE: Genomic sequencing can generate complex results, including variants of uncertain significance (VUS). In general, VUS should not inform clinical decision-making. This study aimed to assess the public's expected management of VUS. METHODS: An online, hypothetical survey was conducted among members of the Canadian public preceded by an educational video. Participants were randomized to 1 of 2 arms, VUS or...
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