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Article

Chromatin remodelling subunit SMARCB1 is implicated in dendrite development and complex brain functions.

Acta neuropathologica communications - 19 Feb 2026

Lemke Kristina I, Filatova Alina, Chiang Joanna, North Hannah, Kamphof Myrthe R M, Becker-Röck Michaela, Laube Bodo, Santen Gijs W E, Swaab Hanna, Nuber Ulrike A

Abstract excerpt

SMARCB1 encodes a core component of the BAF chromatin remodelling complex and pathogenic variants in this gene are associated with neurodevelopmental disorders such as Coffin-Siris syndrome and intellectual disability with choroid plexus hyperplasia. The relationship between reduced or dysfunctional SMARCB1 protein products and severe functional brain changes associated with Coffin-Siris syndrome, including...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41715173
DOI: 10.1186/s40478-026-02258-2
PMCID: PMC12930746

Genes

SMARCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Chromatin remodelling subunit SMARCB1 is implicated in dendrite development and complex brain functions.PMID 41715173Read ↗

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