Article

Chromatin remodelling subunit SMARCB1 is implicated in dendrite development and complex brain functions

2025-10-31

Abstract excerpt

SMARCB1 encodes a core component of the BAF chromatin remodelling complex and pathogenic variants in this gene are associated with neurodevelopmental disorders such as Coffin-Siris syndrome. The relationship between altered SMARCB1 protein products and severe functional brain changes in Coffin-Siris syndrome remains largely unknown. We performed cellular, molecular, and behavioural analyses of a Coffin-Siris syndr...

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Literature Corpus work: 9cc4178c-abef-56a7-95f9-fef73351342c
DOI: 10.1101/2025.10.30.685571

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