Article
PIK3CA Mutations in Early-Onset Appendiceal Adenocarcinoma.
JCO precision oncology - 1 Feb 2026
Gupta Princy, Gujarathi Rushabh, Qiao Lu, Godfrey Elizabeth L, Schultz Kurt S, Butensky Samuel D, Bader Justin M, Sundar Raghav, Cecchini Michael, Shergill Ardaman, Sheltzer Jason M, Turaga Kiran K
Abstract excerpt
PURPOSE: Approximately one in three patients with appendiceal cancer (AC) is diagnosed before age 50 years. Early-onset appendiceal cancer (EOAC) exhibits distinct clinicopathologic and demographic features compared with late-onset disease, suggesting potential biological differences. However, the molecular differences remain poorly understood. This study aims to compare EOAC and late-onset AC (LOAC, ≥50 years)...
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