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Article

Delineating citrinin biosynthesis: Ctn-ORF3 dioxygenase-mediated multi-step methyl oxidation precedes a reduction-mediated pyran ring cyclization.

Bioorganic & medicinal chemistry letters - 15 Jan 2016

Balakrishnan Bijinu, Chandran Ramya, Park Si-Hyung, Kwon Hyung-Jin

Abstract excerpt

Citrinin (3) is a polyketide-derived mycotoxin, that is, produced by Monascus, Penicillium, and Aspergillus spp. and is a common contaminant in a number of agricultural products. ctPKS, a non-reducing type iterative polyketide synthase with a C-terminal reductive domain, is proposed to generate the polyketide backbone of 3. The targeted gene inactivation of ctn-orf1 or ctn-orf3 gene resulted in the accumulation...

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PMID: 26707397
DOI: 10.1016/j.bmcl.2015.12.001

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