Approach to Optimizing Tranexamic Acid Use in Trauma: Potential Utilization of Trauma Phenotypes.

Abstract excerpt

Background: Tranexamic acid (TXA) reduces mortality in patients with trauma; however, optimal patient selection remains unclear. This study aimed to identify trauma subgroups most likely to benefit from TXA administration by integrating systematic evidence mapping with trauma phenotype analysis derived from the Japan Trauma Data Bank. Methods: We conducted a two-phase study: first, a systematic search of MEDLINE,...

Topics

• Humans
• Tranexamic Acid
• Wounds and Injuries
• Phenotype
• Antifibrinolytic Agents
• Hospital Mortality