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Article

Successful reduced-intensity cord blood transplantation in infants with familial hemophagocytic lymphohistiocytosis type 2.

International journal of hematology - 1 May 2026

Yasue Shiho, Fujimori Kentaro, Gocho Yoshihiro, Osumi Tomoo, Iguchi Akihiro, Deguchi Takao, Uchiyama Toru, Kawai Toshinao, Kato Motohiro, Tomizawa Daisuke, Matsumoto Kimikazu, Sakaguchi Hirotoshi

Abstract excerpt

Familial hemophagocytic lymphohistiocytosis type 2 (FHL2) is a rare congenital disorder caused by PRF1 mutations that leads to life-threatening hemophagocytic lymphohistiocytosis during infancy. Hematopoietic cell transplantation (HCT) is the only curative treatment, but optimal transplantation strategies remain unclear. We report two cases of infants with FHL2 successfully treated with cord blood transplantation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41678000
DOI: 10.1007/s12185-026-04174-6

Genes

FHL2
PRF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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