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Article

Allogeneic hematopoietic stem cell transplant for familial hemophagocytic lymphohistiocytosis: a case report and literature review.

Frontiers in immunology - 1 Jan 2024

Bingjie Liu, Linlin Zhang, Futian Ma, Fan Xuan, Huan Du, Wu Xiaoli, Zhou Lixia, Fuxu Wang, Xuejun Zhang, Ying Wang

Abstract excerpt

Objectives: This study aims to discuss the clinical manifestations and treatment of Familial hemophagocytic lymphohistiocytosis (FHL) caused by a mutation in the UNC13D gene. Methods: A 6-year-old female child presented with unexplained febricity, splenomegaly, pancytopenia, hemophagocytic lymphohistiocytosis in bone marrow, decreased NK cell activity, soluble CD25 levels > 44000ng/ml. Genetic sequencing revealed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38887297
DOI: 10.3389/fimmu.2024.1391074
PMCID: PMC11180752

Genes

UNC13D

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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