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Article

Multi-gene co-mutations of BRAF with TERT, PIK3CA, or TP53 are powerful predictors of central lymph node metastasis in papillary thyroid carcinoma.

Frontiers in endocrinology - 1 Jan 2025

Yu Qing, Liu Han

Abstract excerpt

Background: The accurate preoperative prediction of lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) poses a significant clinical challenge. Although clinicopathological features are commonly utilized, their predictive accuracy remains limited, and the role of multi-gene co-mutations is not fully understood. Objective: This study aimed to develop and validate an integrated risk model that combines...

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Topics

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Share to Class I Phosphatidylinositol 3-Kinases
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphatic Metastasis

Share to Proto-Oncogene Proteins B-raf

Share to Telomerase

Share to Thyroid Cancer, Papillary

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Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41675640
DOI: 10.3389/fendo.2025.1728045
PMCID: PMC12886009

Genes

BRAF
PIK3CA
TERT
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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