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Article

Evidence for genetic correlation between appendix and inflammatory bowel disease: A bidirectional Mendelian randomization study.

PloS one - 1 Jan 2026

Liu Dan, Dan Wanyue, Yan Bin, Peng Lihua, Pan Fei

Abstract excerpt

BACKGROUND: Observational studies highlighted a link between the appendix and inflammatory bowel disease (IBD), but proving causality has been difficult due to the lack of a clear temporal sequence. METHODS: This research used a two-sample bidirectional univariable Mendelian randomization (MR), multivariable MR and linkage disequilibrium score regression (LDSC) analyses to explore the relationship between acute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41671252
DOI: 10.1371/journal.pone.0342541
PMCID: PMC12893558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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