Article
The prognostic impact of CDKN2A/B hemizygous deletions in meningioma.
Neuro-oncology - 1 May 2026
Ippen Franziska M, Hielscher Thomas, Patel Areeba, Friedel Dennis, Göbel Kirsten, Sievers Philipp, Acker Till, Snuderl Matija, Brandner Sebastian, Weller Michael, Preusser Matthias, Maas Sybren L N, Deimling Andreas V, Wick Wolfgang, Bi Wenya Linda, Sahm Felix, Suwala Abigail K
Abstract excerpt
BACKGROUND: Meningiomas are the most common adult brain tumors. While homozygous deletions of CDKN2A/B are linked to early recurrence and hence serve as CNS WHO grade 3 criterion, the clinical impact of hemizygous deletions remains unclear-especially since distinguishing between hemi- and homozygous losses can be technically challenging. METHODS: DNA methylation data, copy-number, and mutation data were evaluated...
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