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Article

The crucial but insufficient role of E2s domain's residues 490 and 492 in determining the host tropism of hepatitis E virus.

Nature communications - 9 Feb 2026

Tang Zi-Min, Yang Cheng-Yu, Wen Gui-Ping, Liu Chang, Ying Dong, Huang Yang, Yu Zi-Hao, Li Ming-Yu, Wang Si-Ling, Chen Zi-Hao, Liu Jun-Fei, Fang Mu-Jin, Wang Ying-Bin, Zhang Jun, Gu Ying, Yu Hai, Li Shao-Wei, Zheng Qing-Bing, Xia Ning-Shao, Zheng Zi-Zheng

Abstract excerpt

Hepatitis E virus (HEV) is a significant pathogen causing acute viral hepatitis globally, posing a particular threat to pregnant women. HEV infects a range of host species, with distinct genotypes exhibiting genotype-specific tropism for different host hepatocytes. The P domain of viral capsid protein plays a central role in host cell attachment, but the molecular determinants that govern its host specificity...

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Identifiers

PMID: 41663378
DOI: 10.1038/s41467-026-69125-5
PMCID: PMC12996312

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