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Cell binding tropism of rat hepatitis E virus is a pivotal determinant of its zoonotic transmission to humans

28 Oct 2024

Abstract excerpt

Classically, all hepatitis E virus (HEV) variants causing human infection belong to the genus Paslahepevirus (HEV-A). However, the increasing cases of rat HEV infection in humans since 2018 challenged this dogma, posing increasing health threats. Herein, we investigated the underlying mechanisms dictating the zoonotic potentials of different HEV species and their possible cross-protection relationships. We found...

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PMID: 39467126
DOI: 10.1073/pnas.2416255121

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