Synthesis and functional characterization of a recombinant HIV-1 reverse transcriptase variant carrying twelve drug-resistance mutations as a platform for antiretroviral screening.

Abstract excerpt

HIV-1 multidrug resistance remains a major barrier to effective long-term antiretroviral therapy and highlights the need for robust biochemical models for screening next-generation inhibitors. Reverse transcriptase (RT) is a central therapeutic target whose inhibition is compromised by the accumulation of resistance mutations that alter substrate usage and reduce drug susceptibility. Here, we engineered,...

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