Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell and machine learning integration reveals OS-driven CCND1 promotes an aggressive phenotype in papillary thyroid carcinoma.

Frontiers in immunology - 1 Jan 2025

Wang Jiaxi, Zhu Qingyi, Bie Jingyi, Han Yueyu, Liu Hanqing, Chen Chuang

Abstract excerpt

Background: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with rising incidence worldwide. Oxidative stress (OS), characterized by an imbalance between reactive oxygen species (ROS) and antioxidant defenses, plays a critical role in tumor initiation and progression. However, the specific relationship between OS and PTC remains underexplored, highlighting the need for further...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin D1
Share to Machine Learning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Reactive Oxygen Species

Share to Single-Cell Analysis

Share to Single-Cell Gene Expression Analysis

Share to Thyroid Cancer, Papillary

Share to Thyroid Neoplasms

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 41646983
DOI: 10.3389/fimmu.2025.1722524
PMCID: PMC12871538

Genes

CCND1
SOX4
TFF3
AXL
MDK
PROS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell and machine learning integration reveals OS-driven CCND1 promotes an aggressive phenotype in papillary thyroid carcinoma.PMID 41646983Read ↗

Integrated analysis of tumor microenvironment features to establish a diagnostic model for papillary thyroid cancer by using bulk and single-cell RNA sequencing technologySemantic proximity Read ↗

Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinomaSemantic proximity Read ↗

Distinct molecular subtypes of papillary thyroid carcinoma and gene signature with diagnostic capability.Semantic proximity Read ↗

Integrative transcriptomics and single-cell transcriptomics analyses reveal potential biomarkers and mechanisms of action in papillary thyroid carcinomaSemantic proximity Read ↗

Multi-omics analysis-based macrophage differentiation-associated papillary thyroid cancer patient classifierSemantic proximity Read ↗

Integrated Multi-Omics Bioinformatics and Machine Learning Framework Identifies SPATA18 and IGF2BP2 as Robust Prognostic Biomarkers for Papillary Thyroid CarcinomaSemantic proximity Read ↗

A novel prognostic signature and immune microenvironment characteristics associated with disulfidptosis in papillary thyroid carcinoma based on single-cell RNA sequencingSemantic proximity Read ↗

TLE4 downregulation identified by WGCNA and machine learning algorithm promotes papillary thyroid carcinoma progression via activating JAK/STAT pathwaySemantic proximity Read ↗

Next-generation sequencing identified somatic alterations that may underlie the etiology of Chinese papillary thyroid carcinoma.Semantic proximity Read ↗

Single-cell and bulk RNA sequencing reveal heterogeneity and diagnostic markers in papillary thyroid carcinoma lymph-node metastasisSemantic proximity Read ↗

Single-Cell Transcriptomic Analysis of Ecosystems in Papillary Thyroid Carcinoma ProgressionSemantic proximity Read ↗

Single-Cell RNA Sequencing Revealed a 3-Gene Panel Predicted the Diagnosis and Prognosis of Thyroid Papillary Carcinoma and Associated With Tumor Immune MicroenvironmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.