Article
From molecules to medicine: a future cure for preeclampsia?
Drug news & perspectives - 1 Nov 2009
Santillan Mark K, Santillan Donna A, Sigmund Curt D, Hunter Stephen K
Abstract excerpt
In the United States, preeclampsia (PreE) affects 5-7% of all pregnancies, yet represents 15% of all maternal-fetal morbidity and mortality. PreE causes fetal growth restriction, oligohydramnios, fetal death, and maternal seizures, stroke, cerebrovascular hemorrhage and death. It has immediate and potentially long-term effects on both the fetus and mother. To date, the molecular pathogenesis of PreE is largely...
Topics
- Animals
- Antihypertensive Agents
- Drug Design
- Endothelium, Vascular
- Female
- Genetic Predisposition to Disease
- Humans
- Immune System
- Oxidative Stress
- Phenotype
- Placenta
- Pre-Eclampsia