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Article

Generation of two induced pluripotent stem cell lines from dilated cardiomyopathy patients carrying RBM20 mutations.

Stem cell research - 1 Mar 2026

Sun Shuai, Yang Xiaochun, Zhou Yang, Yu Rebecca, Walther Parker, Teuteberg Jeffrey, Parikh Victoria, Wu Joseph C

Abstract excerpt

Dilated cardiomyopathy (DCM) is a myocardial disease, characterized by ventricular enlargement and reduced contractile ability, which frequently leads to heart failure and arrhythmias. This condition is related to loss-of-function mutations in the RNA-binding motif protein 20 (RBM20), which disrupts target gene splicing. Two induced pluripotent stem cell (iPSC) lines, each harboring a single heterozygous RBM20...

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Cardiomyopathy, Dilated
Cell Differentiation
Cell Line
Induced Pluripotent Stem Cells
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Binding Proteins

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Identifiers

PMID: 41570362
DOI: 10.1016/j.scr.2026.103911

Genes

RBM20

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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