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Article

PAD-associated Genetic Variants are More Strongly Associated with Surgical Intervention than Premature Onset.

Journal of cardiovascular translational research - 5 Feb 2026

Hu Jiaqi, Alameddine Dana, Wang He, Mani Arya, Scharfe Curt, Jiang Yong-Hui, Murray Michael F, Chaar Cassius I Ochoa, DeWan Andrew T

Abstract excerpt

This study explored the association between 19 peripheral artery disease (PAD)-associated variants and PAD severity. We classified PAD cases into 4 groups with increasing levels of severity based on age of PAD diagnosis and surgical status. Genetic association analysis for PAD severity and markers was conducted using REGENIE, and a 19-variant polygenic risk score (PRS) was developed to further evaluate the...

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PMID: 41642540
DOI: 10.1007/s12265-025-10737-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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