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Assessment of mutagenic potential of puberulic acid contaminated in red yeast rice (beni-koji) health food supplements.

Mutagenesis - 24 Apr 2026

Sugiyama Kei-Ichi, Furuhama Ayako, Horibata Katsuyoshi, Tsuda Masataka, Izawa Kazuki, Tsuji Genichiro, Demizu Yosuke, Matsushita Kohei, Toyoda Takeshi, Hirabayashi Yoko, Saito Yoshiro, Honma Masamitsu

Abstract excerpt

In March 2024, a food poisoning incident in Japan was traced to red yeast rice (beni-koji) supplements contaminated with puberulic acid (PA), a mycotoxin produced by Penicillium adametzioides. Although PA was implicated in renal dysfunction in both humans and rats, its mutagenic potential had not been clarified. Here, we comprehensively assessed the mutagenicity of PA using a tiered approach that combined in...

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Biological Products
Coumaric Acids
Dietary Supplements
Food Contamination
Mutagenicity Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41641978
DOI: 10.1093/mutage/geag005
PMCID: PMC13107177

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