Article

The pathogenesis of common Gjb2 mutations associated with human hereditary deafness in mice

2023-01-06

Abstract excerpt

<title>Abstract</title> <p>Mutations in <italic>GJB2</italic> (Gap junction protein beta 2) are the most common genetic cause of non-syndromic hereditary deafness in humans, especially the 35delG and 235delC mutations. Owing to the homozygous lethality of <italic>Gjb2</italic> mutations in mice, there are currently no perfect mouse models carrying <italic>Gjb2</italic> mutations derived from patients for mimickin...

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Literature Corpus work: c3678580-e7f5-5626-8ada-6c79271c0e30
DOI: 10.21203/rs.3.rs-2419083/v1

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