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Raman and SERS analytical platform with machine learning for classifying wild type p53 and hotspot mutants R175H and R273H.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy - 5 May 2026

Hernández-Vidales Karen, Muñoz Castillo Juan A, Islas Selene R, Rodríguez-Rodríguez Andrés, Olivares-Illana Vanesa, Saniger José M

Abstract excerpt

The development of analytical approaches capable of detecting subtle protein conformational changes is of significant interest in biomedicine, particularly for disease diagnostics and biomolecular characterization. In this work, the tumor suppressor p53 protein was selected as a model system to evaluate an analytical platform based on Raman spectroscopy combined with surface-enhanced Raman spectroscopy (SERS) and...

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PMID: 41633270
DOI: 10.1016/j.saa.2026.127522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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