Article

Amyloidogenic regions in beta-strands II and III modulate the aggregation and toxicity of SOD1 in living cells

2023-10-19

Abstract excerpt

Mutations in the protein superoxide dismutase-1 (SOD1) promote its misfolding and aggregation, ultimately causing familial forms of the debilitating neurodegenerative disease amyotrophic lateral sclerosis (ALS). Currently, over 220 (mostly missense) ALS-causing mutations in the SOD1 protein have been identified throughout the primary sequence, indicating that common structural features responsible for aggregation...

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Literature Corpus work: 217498bc-bab5-52c0-b530-5340b657f267
DOI: 10.1101/2023.10.18.562627

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