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Article

Integrative causal inference and predictive modeling reveal the iron-related gene SLC17A4 as a key biomarker in chronic rhinosinusitis.

Frontiers in immunology - 1 Jan 2025

Lv Jiajia, Jiang Feifei

Abstract excerpt

Purpose: To investigate whether iron metabolism exerts a causal influence on chronic rhinosinusitis (CRS) and to identify iron-related biomarkers and regulatory genes with diagnostic and therapeutic potential. Methods: A two-sample Mendelian randomization (MR) analysis was conducted using large-scale GWAS summary statistics for four iron-related traits and three nasal inflammatory diseases. Significant SNPs were...

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Identifiers

PMID: 41613149
DOI: 10.3389/fimmu.2025.1645726
PMCID: PMC12847307

Genes

SLC17A4

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