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Genetic polymorphisms in headache attributed to temporomandibular disorder: A case-control study.

Archives of oral biology - 1 Apr 2026

Campello Camilla Porto, Lemos Cleidiel Aparecido Araujo, Lima Elker Lene Santos de, Fernandes Renata Silva Melo, Muniz Maria Tereza Cartaxo

Abstract excerpt

OBJECTIVE: The aim of this study was to examine the relationship between three single nucleotide polymorphisms (SNPs): -308 G/A TNF-α, -174 G/C IL-6, and C677T MTHFR and the presence of headache attributed to temporomandibular disorder (HATMD). DESIGN: This case-control study included a total of 68 patients with HATMD and 200 controls, aged 18 years and older. Both sets of participants included both genders. The...

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PMID: 41610735
DOI: 10.1016/j.archoralbio.2026.106523

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MTHFR
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