Association of CYP2C19 gene single nucleotide polymorphisms (rs12248560 and rs4244285) with response to thalidomide in transfusion dependent β-thalassemia patients- a 12-months follow-up study.

Abstract excerpt

AIM: This study aimed to evaluate the efficacy of thalidomide in transfusion-dependent β-thalassemia (TDT) patients and explore its association with CYP2C19 polymorphisms (rs12248560 and rs4244285). METHODS: Hemoglobin levels of 190 TDT patients were assessed at baseline and after 3, 6, and 12 months of thalidomide treatment. Patients were categorized into response groups based on Hb improvement. Genotyping of...

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