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Article

A Pragmatic Scoring Tool to Predict Hydroxyurea Response Among β-Thalassemia Major Patients in Pakistan.

Journal of pediatric hematology/oncology - 1 Jan 2022

Ansari Saqib H, Hussain Zeeshan, Zohaib Muhammad, Parveen Sadia, Kaleem Bushra, Qamar Hina, Adil Omair, Khan Muhammad T, Shamsi Tahir S

Abstract excerpt

Despite high prevalence and incidence of β-thalassemia in Pakistan, there is very limited work on the use of hydroxyurea (HU) in thalassemia patients in the country. This is the first insight regarding genetic profiling of BCL11A and HU responses in Pakistani β-thalassemia. It correlates single-nucleotide polymorphisms on BCL11A (rs4671393, rs766432) and HBG2 (XmnI), age at first transfusion, and β-globin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33710118
DOI: 10.1097/MPH.0000000000002136

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