Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension.

doi:10.1161/CIRCULATIONAHA.125.079067

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Article

Breast Cancer Reveals Latent BMPR2-Related Susceptibility to Pulmonary Hypertension.

Circulation - 17 Feb 2026

Toro Victoria, Mougin Manon, Brossat Coline, Jambon-Barbara Clement, Hlavaty Alex, Guay Charles Antoine, El Kabbout Reem, Bilodeau Coralie, Grobs Yann, Martineau Sandra, Breuils-Bonnet Sandra, Abi-Sleimen Antonella, Ruffenach Gregoire, Boucherat Olivier, Bisserier Malik, Provencher Steeve, Bonnet Sebastien, Montani David, Khouri Charles, Potus François

Abstract excerpt

BACKGROUND: Pulmonary arterial hypertension (PAH) and breast cancer disproportionately affect women. BMPR2 (bone morphogenetic protein receptor type 2) mutations, the most common genetic cause of heritable PAH, also exert tumor-suppressive functions, but their role in linking these diseases remains unclear. METHODS: We combined bioinformatic, epidemiologic, and experimental approaches. Public cancer datasets were...

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Identifiers

PMID: 41603037
DOI: 10.1161/CIRCULATIONAHA.125.079067
PMCID: PMC12908636

Genes

BMPR2
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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