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Article

Single-Nucleus Transcriptional Profiling Revealed Cell Diversity and Albino Mutation Mechanism in the Skin of Channa argus.

International journal of molecular sciences - 20 Jan 2026

Zhang Lu, Zhou Jian, Li Qiang, Ke Hongyu, Huang Zhipeng, Zhao Zhongmeng, Zhao Han, Mou Chengyan, Fan Wei, Duan Yuanliang

Abstract excerpt

Body color is the most prominent phenotypic trait in animals. To investigate the molecular regulatory mechanisms underlying skin pigmentation and body color in Channa argus, single-nucleus RNA sequencing technology was employed to analyze cell diversity and functional changes in the skin of normal and albino C. argus. Three pigment-related cell types, seven immune-related cell types, and nine other skin-related...

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Identifiers

PMID: 41596666
DOI: 10.3390/ijms27021023
PMCID: PMC12841621

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