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Article

Characterization of pulmonary tuberculosis in high-altitude region using nanopore targeted sequencing.

BMC microbiology - 26 Jan 2026

Xia Anyue, Zhong Qiu, Yu Xiaohui, Liu Shiying, Lin Jingyu, Ding Sijuan, Feng Dongfang, Zhu Bin, Li Maoshi, Li Shangshi, Zeng Xianglong, Xu Huan

Abstract excerpt

BACKGROUND: Xizang (formerly known as Tibet in English) has one of the highest tuberculosis (TB) incidence rates in China. The region's extreme altitudes (≥ 3000 m) and hypoxic environment present substantial challenges for conventional diagnostic methods. Additionally, the clinical and biological characteristics of TB at high altitudes remain poorly understood. METHOD: TB-seq, a third-generation...

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PMID: 41588322
DOI: 10.1186/s12866-026-04761-x
PMCID: PMC12914938

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