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Article

JAG1 of all trades, master of CKD? The role of JAG1 in autosomal dominant tubulointerstitial kidney disease.

Kidney international - 1 Feb 2026

Wiesener Michael S, Olinger Eric

Abstract excerpt

The current study by Menguy et al. describes JAG1 as a novel candidate gene for the spectrum of autosomal dominant tubulointerstitial kidney disease. Patients have been shown to develop fibrosis and chronic kidney disease, when distinct pathogenic germline variants occur in JAG1. Interestingly, genetic alterations in the Jagged1/Notch2 pathway can cause the variable appearance of Alagille syndrome, which may also...

Topics

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Alagille Syndrome
Calcium-Binding Proteins
Intercellular Signaling Peptides and Proteins
Jagged-1 Protein
Nephritis, Interstitial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptor, Notch2

Renal Insufficiency, Chronic

Serrate-Jagged Proteins

Source

Identifiers

PMID: 41577389
DOI: 10.1016/j.kint.2025.11.006

Genes

JAG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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