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Article

Advancements in targeted therapies for acute myeloid leukemia.

Current opinion in pharmacology - 1 Apr 2026

Connor Matthew P, Barsouk Adam, Elghawy Omar, Lai Catherine

Abstract excerpt

For decades, the only therapeutic option for acute myeloid leukemia (AML) had been intensive combination chemotherapy. In recent years, understanding of the molecular mechanisms underlying myeloid oncogenesis has grown immensely and has led to the development of multiple effective small molecule inhibitors of aberrant cellular signaling. This review highlights the major AML mutational pathways currently being...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41576755
DOI: 10.1016/j.coph.2025.102604
PMCID: PMC13218284

Genes

FLT3
IDH1
IDH2
KMT2A
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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